The concept of co-evolution has been most commonly applied to a biological context involving living organisms and nature-based adaptations, but it can be applied to technological domains as well. Cybersecurity strategies based solely on technological features of attack-and-defend adaptations do not immediately reveal a co-evolutionary relationship and are typically seen more as cyber arms races. In order to leverage cyber co-evolution in support of cybersecurity, the human-driven behaviors of cyberattack-and-defend adaptations have to be incorporated. In other words, the mission must serve to drive human motives and goals, and in many cases, must limit the scope of an attacker’s adaptations.